Noninvasive preimplantation genetic testing for aneuploidy in spent blastocyst media will substitute for trophectoderm biopsy
نویسندگان
چکیده
منابع مشابه
What next for preimplantation genetic screening (PGS)? Experience with blastocyst biopsy and testing for aneuploidy.
Blastocysts more commonly have a normal karyotype than cleavage-stage embryos do. Moreover, blastocysts have also made a metabolic transition from catabolism and recycling of the oocyte's reserves and resources, processes that fuel the first 3 days of cleavage. Although not all blastocysts are karyotypically equal, it is still to be determined to what extent a mosaic karyotype might be a normal...
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Is the timing of vitrification after trophectoderm (TE) biopsy associated with successful implantation and pregnancy after the embryo transfer of blastocysts subjected to preimplantation genetic screening (PGS)? In this retrospective cohort study, 1329 blastocysts from 223 patients were subjected to TE biopsy for performing array comparative genomic hybridization (CGH) tests. The PGS and frozen...
متن کاملComparison of noninvasive prenatal testing of cell‐free DNA in maternal blood and amniocentesis for evaluation of aneuploidy
Background: The aim of this study was to compare noninvasive prenatal testing (NIPT) of cell‐free DNA in maternal blood and amniocentesis in the diagnosis of aneuploidy. This study was designed to evaluate sensitivity, specificity, accuracy, positive predictive value and negative predictive value of NIPT for detection of aneuploidies compared gold standard test of amniocentesis. Materials and m...
متن کاملBlastocyst biopsy and preimplantation genetic diagnosis for single gene diseases: a turnaround on the horizon?
In this issue of RBM Online, two independent studies, Feng et al. (2012) and Lathi et al. (2012), confirm the conclusions of an earlier cohort study on comparative genomic hybridization (CGH) after trophectoderm biopsy and vitrification (Schoolcraft et al., 2010). Feng and co-workers demonstrate that vitrification and warming of blastocysts has minimal effect on their viability, while Lathi and...
متن کاملBlastocyst biopsy and vitrification are effective for preimplantation genetic diagnosis of monogenic diseases.
STUDY QUESTION What is the value of a new strategy for preimplantation genetic diagnosis (PGD) of monogenic diseases: blastocyst biopsy, cryopreservation and thawed embryo transfer? SUMMARY ANSWER This strategy is highly effective for PGD of monogenic diseases and merits wide use. WHAT IS KNOWN ALREADY PGD of monogenic diseases is conventionally performed on 6- to 8-cell embryos with fresh ...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2021
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2021.02.046